Liverpool climbed to the top of the Premier League table with a 2-1 victory over struggling Wolverhampton Wanderers on Saturday.
All eyes will be on Manchester United manager Louis van Gaal when he takes his team to Derby County for an FA Cup fourth-round tie on Friday with the fans' boos from their home defeat by Southampton still ringing in his ears.
As Jose Mourinho returns to his Portuguese footballing roots, the Chelsea manager may have to decide which back-up marksman he trusts most to shoot down his old employers at Sporting Lisbon in the Champions League on Tuesday.
Liverpool's Slot not nervous ahead of Anfield debut
Manchester United's current malaise was laid bare as they struggled past third-tier Rochdale 5-3 on penalties after a 1-1 draw in the League Cup third round.
IMAGES from the English Premier League matches played on Saturday.
Chelsea overpowered West Ham United and Manchester City outclassed West Bromwich Albion as the Premier League title rivals signalled their intent at the start of a hectic holiday programme on Friday.
News of all that's transpired on and off the football field
IMAGES from the English Premier League matches played on Saturday
Arsenal's improbable late run at the Premier League title gained momentum with a 1-0 victory at struggling Burnley on Saturday, an eighth straight triumph that moved them within four points of leaders Chelsea.
The Gunners' only league defeat of the campaign was in September away to one of England's traditional top-six clubs, Manchester United, drawing criticism that their strong start to the season was based on wins against lesser opposition.
Premier League champions Chelsea, beginning to find their form under Guus Hiddink after a shocking start to the season, will face Manchester City in the outstanding tie of the FA Cup fifth round following Sunday's draw.
IMAGES from the English Premier League matches played on Wednesday.
Manchester City were confirmed as English Premier League champions for the fifth time in six seasons on Saturday without even having to kick a ball.
Realistically, the Foxes, who beat Chelsea in the FA Cup final last Saturday, need to win and hope one of their rivals slip up.
Manchester City took another decisive step toward an unprecedented fourth successive Premier League title with a 4-0 demolition of Fulham.
Manchester United won 2-1 at Crystal Palace to consolidate fourth spot.
Manchester United midfielder Bastian Schweinsteiger is unlikely to play for his club again season due to a knee injury, manager Louis van Gaal said on Friday.
The battle for Champions League qualification continues with fourth-placed Aston Villa away to Luton Town on Saturday and Tottenham Hotspur, who are five points behind with a game in hand, hosting Crystal Palace.
Pressure is something that Liverpool manager Brendan Rodgers says comes with the territory, but after a dismal run, the odds on him becoming the season's first managerial casualty are swiftly shortening.
Manchester City climbed back into the Premier League's top four as second-half goals by Phil Foden, Julian Alvarez and Bernardo Silva sealed a comeback 3-1 victory at Everton on Wednesday.
Lallana signs short-term Liverpool extension
Eden Hazard and Fernando Torres applied the gloss to a workmanlike 2-0 victory at Hull City that lifted Chelsea ominously to the top of the Premier League on Saturday.
Manchester City can pile the pressure on Premier League leaders Chelsea for the first time this season.
Images from Saturday's action in the Premier League.
After seven consecutive league defeats, and one point from the last 30 on offer, had plunged Villa into crisis and cost Tim Sherwood his job, the former European champions produced a gritty display to frustrate City.
Thierry Henry has been named head coach of the country's Under-21s until 2025
Burnley's 0-0 draw at home to Tottenham Hotspur in the Premier League on Sunday completed a profitable weekend for the three clubs bidding to avoid a swift return to the second tier of English football.
Stevan Jovetic and Jesus Navas scored their first goals for ManchesterCity who avenged last season's shock FA Cup final defeat by Wigan Athletic with a 5-0 victory in the League Cup third round on Tuesday.
Leicester's EPL title credentials on show against champions Chelsea.
Everton's Premier League match at home to Manchester City on Monday has been called off due to new COVID-19 cases reported at City.
Liverpool are champions and Norwich City, the side whom they beat on Aug. 9 to launch their title charge, are down and Manchester City are distant runners-up. After that everything is up for grabs.
The destination of the Premier League trophy will not be decided when current champions Chelsea meet their immediate predecessors Manchester City.
Brighton and Hove Albion scored late to earn a 1-1 draw at Crystal Palace. Sheffield United and Fulham also drew 1-1 as both teams picked up their first points.
Chelsea and Manchester City tightened their stranglehold on the Premier League title race on Saturday, recording victories over struggling clubs to stretch further clear of their increasingly forlorn pursuers.
Chelsea captain John Terry is showing all the qualities of a future manager, the club's interim boss Guus Hiddink said on Friday. Terry, 35, is keen to continue his playing career at Stamford Bridge but has not yet been offered a new contract for next season. Hiddink said decision was not down to him, but in the longer term he could see the former England central defender as a manager. "In some players you see while they are playing there might be managers inside them already," the Dutchman told a news conference. "You see that most of the time in midfield positions or centre-backs. These guys are already leaders. "In my career I've had some examples like (Southampton's) Ronald Koeman in my first spell at Eindhoven, who you could see was tactically very strong and a leader. "And (Watford's) Quique Sanchez Flores at Valencia too." Terry would need "extra courses" and would be well advised to start as an assistant, Hiddink added.
Images from the English Premier League matches played on Wednesday night.
Real Madrid's Karim Benzema, who won the 2022 Ballon d'Or award, is also in the shortlist.
Manchester City goalkeeper Joe Hart generated some more negative headlines after a last minute mix-up with Matija Nastasic allowed Chelsea's Fernando Torres to score a late winner in a 2-1 victory at Stamford Bridge on Sunday.
Manchester City and Arsenal closed in on Premier League leaders Liverpool with contrasting victories on Saturday as Manchester United's bubble was burst by Fulham.